Hsu Wei-Hui was born in 1979 in Taoyuan, Taiwan. She received her BEd degree with a major in Fine Arts from the National Hsinchu University of Education in Taiwan. She went to the US in 2004 and received her MA degree in Painting from the Savannah College of Art and Design in Savannah, Georgia. Later on, she received her MFA degree from the Cranbrook Academy of Art, Bloomfield Hills, Michigan. Hsu Wei-Hui joined artist-in-residence programs in Seoul, Korea in 2007 and in Vermont, US in 2009. She received a Merit Award from Creative Quarterly Magazine, New York in 2008, and also received Lenore Segan Arts Awards from the Joyce Dutka Arts Foundation, New York. In 2014, her work Smiling Face as a Flower - Resplendent-6 was collected by the National Taiwan Museum of Fine Arts.
She makes full-scale installations as well as smaller mixed media pieces. Her works have been exhibited at alternative spaces, galleries, and museums in Taiwan, China, Japan, Korea, the US, Canada, Italy and the UK.